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Two studies zero in on DNA-based drivers of weight. Is obesity written in our genes? In two separate papers, published in the journal Science and in the Journal of Clinical Investigation (JCI), researchers describe new genetic factors that could explain weight gain in some people. In the Science study, researchers at Boston Children’s Hospital studying mice found a rare genetic mutation that prevented the animals from burning off fat calories. They also found the same gene was mutated in a group of obese people. And a team based at University College London reported in JCI that a specific form of a gene previously linked to obesity, FTO, can increase craving for high-fat foods. The discoveries add to the growing body of knowledge about the biology behind weight, and the results confirm that while it’s represented by a single number, weight is the complex combination of a multitude of different metabolic processes, from brain systems that regulate appetite to enzymes that control how efficiently calories are turned from food into energy that the body needs. Making matters even more confusing, these factors are also likely influenced by environmental contributors such as diet and lifestyle.

obesity

Medical Conference, Boise, Idaho, 2010

Unless it is digging your own grave. Go on and make your fingers hurt. It makes me feel GOOD! Unless you want to dig your own grave

fingershurt

youtube online

ole'

ngeole

A mariachi CD that had like 7 random tracks, it's also on youtube if I'm correct.

I found out what is probably an old trick, that being that you can import a bitmap as an audio file and put effects on it as if it were audio. So I found a nice tasteful photograph of a duck and set to work. In my case this was done in audacity, imported as raw A-law encoded audio. Echo was added at different settings and then saved as A-law. This clearly makes me an artistic and very deep person. But seriously I probably will look into using this more in the future in creative ways. The music is me messing around with a melodica with some echo and stuff heaped on.

artisticduck

me

a kek so top it spins on its head

homelady

simpsons mp3

NU is a tier packed full of potential Stealth Rock users, many of whom share one of Golem's typings. However, there are many different reasons to choose Golem for a slot on your team. The best reason to choose Golem for your team is its dual Ground / Rock typing, which no other common Pokemon in NU shares. This allows it to take Flying-type moves with ease while also being immune to Electric-type attacks. It also gives Golem an additional STAB move to utilize, which Pokemon like Gigalith would love to have. Additionally, Golem is one of only a few Pokemon in the tier that is nearly guaranteed to set up Stealth Rock thanks to Sturdy, allowing Golem to live any one hit from full HP unless the opposing Pokemon has Mold Breaker. With these things in mind, Golem is usually better suited for more offensively oriented teams. Finally, while Golem may have exploitable Grass-, Water-, and Ground-type weaknesses and a low Special Defense stat, it is still a great Stealth Rock user that gets its job done well.

kalel

Michael Keaton

stop goofing around!

gowi

Monty Python & The Holy Grail

This set aims to scout your opponent's team while maintaining offensive momentum. Fake Out always causes a flinch and packs decent power when boosted by Technician. U-turn keeps up momentum by bringing in an appropriate check or counter to whatever is out on the field. Taunt prevents the target from using non-attacking moves, which shuts down walls such as Alomomola and also prevents entry hazards, a great plus because of Persian's tendency to switch. Bite can be used instead of Taunt as it allows Persian to hurt Ghost-types, packing decent power with Technician and a good chance to cause a flinch. Keep in mind, however, that pairing Persian with a Ghost-type check handles most Ghost-types well enough, meaning that Bite is often unnecessary. Return is used as a strong STAB attack that can finish off any weakened opponents.

noimnot

Unlike Pilleater and all of its alts

When life gets you down and you feel like you just can't go on anymore, just know that Pavement Bee has it worse.

pavementbee

Untitled - Simple Plan

Come on , shake your body baby, do the conga I know you cant control yourself any longer Come on , shake your body baby, do the conga I know you cant control yourself any longer Come on , shake your body baby, do the conga I know you cant control yourself any longer Feel the rhythm of the music getting stronger Dont you fight it til you tried it, do that conga beat Everbody gather round now Let your body feel the heat Dont you worry if you cant dance; Let the music move your feet Its the rhythm of the island, and like the sugar cane so sweet If you want to do the conga, youve got to listen to the beat Come on , shake your body baby, do the conga I know you cant control yourself any longer Feel the rhythm of the music getting stronger Dont you fight it til you tried it, do that conga beat Feel the fire of desire, as you dance the night away cause tonight were gonna party, til we see the break of day Better get yourself together, and hold on to what youve got Once the music hits your system, theres no way your gonna stop (repeat 3xs) come on , shake your body baby, do the conga I know you cant control yourself any longer Feel the rhythm of the music getting stronger Dont you fight it til you tried it, do that conga beat Come on , shake your body baby, do the conga

comeonshakeyourbodybaby

Youtubed the gloriast of estefans

In his racist (or was it instead, or partially, sexual-insecurity based) rant, the soon-to-be former owner of the Clippers, Donald Sterling, also suggests that the nation of Israel is racist toward black people, similar to racism black people in the U.S. faced before the Civil Rights Act of 1963 was passed. I think this accusation is worth investigating, and, if true, the corrupt Israeli government MUST BE PRESSURED INTO ENSURING THAT ALL ISRAELI CITIZENS, REGARDLESS OF RACE, BE GRANTED EQUAL OPPORTUNITY TO SUCCEED IN ISRAELI SOCIETY! Please also note that I am not saying that Jews are racist, but that the corrupt Israeli government has a lot to answer for, similar to other corrupt national governments like those of Uganda, Iran, and, yes, the United States of America. I'm also not denying that Sterling is a racist piece of crap because he is. But there's more going on than just his racism here. I also think Sterling leaked this himself to accelerate any sales of the Clippers so he can offload them as quick as possible to retire as quick as possible, and really does not care what the public thinks of him.

donaldsterlingisraelracism

http://613.nashownotes.com

when i'm tuckered out from playing spider solitaire on windows, i take a load off with a nice cup of tahinis from parker bros. uh oh, looks like nessy's at it again ;) I guess i'll dematerialize over to the breakroom and jerk my gherkin. c'mon jar! you're going inside my butt!

tahini

[site davros:site]

when the doctor visits the set of "honey we shrunk ourselves" on his "tour de 1997" he gets more than he bargained for! turns out the shrink ray was almost real! the doctor thought something suspicious was going on so he hid behind a plant until nightfall and then went to do some snooping around. he heard someone tinkering around in the backstage area it was rick morantis! he was pouring into the prop shrink ray some kind of clear blue liquid he was startled. who the hell are you he demanded. oh me well i'm the doctor he said all sly and shit. what are you doing with there? this is just ordinary window cleaner said rick. BULLSHIT i know depropifying fluid when i see it. you're gonna make that shrink ray REAL. WHY??? So I can shrink my humungous penis down to a normal size, said rink. I'm starting to get typecast. But your huge penis saves the planet in about 200 years, said the doctor. Once you finally except your penis for WHO YOU ARE you begin to make plastic molds of it around the world. then when the aliens come to destroy they can see all the giant dildos from OUTER SPACE and return home to figure out how to fight them. but they never make it home because they forgot to fuel up when they had the chance. rick says ok so why don't i just shrink my cock and then make huge dildos anyway? It doesn't work like that screamed the doctor! it's only in the honor of a LEGEND that they will wield their dildos so ferociously. so anyway they go back and fourth like this for a while but eventually he agrees not to shrink the dink. However he does notice a tiny piece of coconut on his upper lip and screams YOU STOLE MY MOUNDS BAR and turns the shrink ray on him and then pretends to go on a tour of the wheaties factory and drops him in a box marked "WHEATIES" iTHINK he explains all this to the guy having breakfast and they sort the whole thing out.

rpg

mario rpg

mfw is a really stupid acronym. Also, I worked really hard on this and it looks really pretty.

mfwmfw

Ochre - Self Assembly

It does what it says on the tin.

detonatorpriest

Squarepusher "Panic Massive"

Florence + The Machine overlaid with "Old School" (2003) This has been sitting on my desktop for months, finally finished it tonight. Had to go to a mental ward for three months after being kidnapped by violent gunmen. Life is cool.

ihadadreamaboutoldschool

"Only If For A Night" slightly edited and shortened.

I'm awake and up at 7am on a saturday. happy 100th birthday to me! Have ya seen how expensive everything is now? And the politics! They just don't make flying cars like they used to. I remember when Apple-Subaru made a gene swapping mind-hoarder sedan for under 5.99999 Earth Coins. It could retrieve the memory of where you were going and doing before the Ultra-Police got clearance to cease fire and extract you from your safety canister! And didn't even download the newest crippling software update till after you came to a complete stop. Bah I forget. how many earth coins for a gallon of milk? or is that illegal now. i heard cows got the right to vote or something. And got granted "endagered species" status! So they actually vote first. You don't know humility till you have to wait at the back of the line in the county free speech zone for a voting kiosk after thirty head of Holstein. I know. I know that makes me sound like a biggot nowadays, but that's what we used to call 'em and it just sticks with ya. Society will be more fair for the cows once all us centenarians die off. And good luck getting your death permit on time! It was nice to see the word "shazbot" finally recognized as an Official Offensive Term by the Bureau of Alcohol, Milkweed and Assault-Words though Ok this somehow went from asinine to "oh shit, they're gonna take it all when I die if I don't get that damn permit" real fast No biggies. We'll hear the Jingle of the Pharmacy truck bells coming down the street in no time and shamble out to meet Doctor Driver. He'll lean down and drop us a wry wink with his flashy smile and might just have us a spare ice-cold selective memory deleting suppository in one of his famous "spare" envelopes. That driver... he's going places!

futurepharmacy

Mister softee

The heat is on. It is, look.

the-heat-is-on

Glen Frey

I take no credit, but it needed to be on YTMND with the song. Original reddit thread: http://www.reddit.com/r/dogecoin/comments/22fyoy/dogecoin_animated_gif/ Creator: http://www.reddit.com/user/Fred_237

dogecoinmachine

Peewee's Big Adventure

New electro track from David Guetta feat. Skylar Grey Available on itunes : http://smarturl.it/DG_ShotMeDown SHARE on Facebook: https://www.facebook.com/sharer/share... SHARE on Twitter: https://twitter.com/home?status=New%2... SUBSCRIBE for more Guetta: http://www.youtube.com/subscription_c... www.davidguetta.com

elfvur

Nice

small weiner

wueirwnwe

and u can slide on it

Windows XP is dying April 8. While this is probably a good thing as everyone else stopped supporting it years ago, there was just something inherently FUN about Windows XP, and it will be missed.

yourfinalrestingday

Found on the album Americana, although someone else ripped it as I can't be bothered converting my rip to mp3

js

severasse

Found this on youtube, its a hot jam.

ｇｕｅｓｓ  ｉ＇ｍ  ｄｏｉｎｇ  ｆｉｎｅ

guessimdoingfine

exceeds the deceptions of nostalgia through a series of instances, situations, moments, and memories that aren't observable or detectable, suggesting the listener to establish their own feelings based on the abstractions at ear. Whether or not these feelings are positive or negative, this does not mourn and does not deceive. It simply exists.

it's like Cheetahmen II on NES, the levels aren't adding up

umfuldmuseumpart3

pokemon x on teh 3ds (xl for me!)

EasyGif Animator pretty much poops on anything it compresses; Why do I still use it? After screwing up 3 years in a row it was time for some time

deathcannon

yeah yeah sure sure

You knew it was coming when you saw the headlines.

ripneckbeard

They charged into the cockpit: Lando's tongue buried in Leia's mouth, her legs wrapped around his waist. He slammed her down on the command console, pinning her there while he undid his pants. "Wait," he said, looking through the viewport. "They'll see us." "They won't," Leia groaned impatiently. "I'm pretty sure they can see us. Look, that one's waving!" "So let 'em watch." She kissed him hard, all tongue. "Give it to me! Kriff me like one of your Twi'lek whores!" Lando wasn't about to deny her anything, pulling his cock free and guiding it between her strong thighs. "Wait," she said, still just barely able to control herself. "I feel so guilty about this, now that Han is dead." Lando simply sneered as he penetrated, then proclaimed "Lando is not!"

I saw it on a GIF with sound comp. All rights reserved to Mr. JamaicanBaconify and that arabian guy who recorded the ostrich.

ostrichrun

Paul Engermann - Push it to the limit

She's got it goin' on.

CinnamonGenesis

staceys mom

She's got it goin' on.

GenesissMom

sTACEYS mOM